Yes, Polkadot can connect to Ethereum and Bitcoin using the Bridge Hub system chain. Snowbridge is an example of an operational trustless bridge between Polkadot and Ethereum. Snowbridge does not depend on trusting centralized entities to relay messages. Hyperbridge is a roll-up chain secured by Polkadot that trustlessly bridges multiple blockchains, including Ethereum, Arbitrum, Base, Binance Smart Chain, Optimism, and Gnosis.